Grandmothers' unhealthy diets may predispose subsequent generations to breast cancer

One of the biggest contributors to adult cancers is an unhealthy childhood diet.1

Cancer takes years and years to develop. In fact,  a woman's diet during pregnancy is known to influence the risk of childhood cancers in her children.2 A woman’s risk of breast cancer similarly is influenced during fetal development by her mother’s dietary habits.3 But breast cancer risk may begin even earlier than this.

An animal study suggests that breast cancer risk may be transmitted even from previous generations – that a grandmother’s unhealthy diet may translate into increased breast cancer risk for her granddaughters. 

The researchers conducted their study as follows:  A generation of female rats (grandmothers) was fed either a normal or high-fat diet during pregnancy - the high-fat diet provided an excess amount of omega-6 fat, attempting to partially mimic the standard American diet, with its abundance omega-6-rich animal products and oils.  Mother and granddaughter rats were fed a normal diet, and granddaughter rats either had two normal diet grandmothers, two high-fat diet grandmothers, or one of each. “Granddaughter” rats were given a chemical carcinogen to initiate breast cancer, and researchers recorded whether or not they developed tumors.4

These were their findings:

  • 50% of the rats with two normal diet grandmothers developed breast tumors
  • 68% of the rats with one high-fat diet grandmother developed breast tumors
  • 80% of the rats with two high-fat diet grandmothers developed breast tumors5

Based on these results, an unhealthy diet may cause inheritable changes in gene expression, causing subsequent generations to be more susceptible to breast cancer-initiating factors such as chemical carcinogens. Family-related risk of breast cancer is usually thought to be related only to specific genes, such as BRCA1 and BRCA2, which are known to increase breast cancer risk. However, this study points to non-genetic, but family-related transmission of risk via dietary habits.

These findings imply that what mothers eat during pregnancy not only affects their children, but their children’s children as well.



References:

1. Maynard M, Gunnell D, Emmett P, Frankel S, Davey Smith G. Fruit, vegetables, and antioxidants in childhood and risk of adult cancer: the Boyd Orr cohort. JEpidemiol Community Health. 2003 Mar;57(3):218-25

2. Kwan ML et al. Maternal diet and risk of childhood acute lymphoblastic leukemia. Public Health Rep. 2009 Jul-Aug;124(4):503-14.

Tower RL et al. The epidemiology of childhood leukemia with a focus on birth weight and diet. Crit Rev Clin Lab Sci. 2007;44(3):203-42.

Petridou E et al. Maternal diet and acute lymphoblastic leukemia in young children.Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1935-9.

Jensen CD et al. Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States).Cancer Causes Control. 2004 Aug;15(6):559-70.

Huncharek M et al. A meta-analysis of maternal cured meat consumption during pregnancy and the risk of childhood brain tumors. Neuroepidemiology. 2004 Jan-Apr;23(1-2):78-84.

3. De Assis S, Hilakivi-Clarke L. Timing of dietary estrogenic exposures and breast cancer risk. Ann N Y Acad Sci. 2006 Nov;1089:14-35.

4. De Assis S, Cruz MI, Warri A, et al. Exposure of rat dams to a high-fat or estradiol-supplemented  diet during pregnancy alters mammary gland morphology and increases mammary cancer risk in their daughters and granddaughters. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; 2010. Abstract number 2931

5. Callaway E. New Scientist. Rats on junk food pass cancer down the generations. http://www.newscientist.com/article/dn18799-rats-on-junk-food-pass-cancer-down-the-generations.html

Food Revolution: 19126 style

Here in my hometown of 19126 we have our local public school system featuring the famous Jamie Oliver’s menus and recipes. A third grade student was inspired by Jamie’s Food Revolution and approached school officials to set aside this week as “Food Revolution Week.” 

Nicholas brought his passion for leading a healthy lifestyle, his love of good food and his interest in the Food Revolution straight to the negotiating table. Through his efforts, Nicolas has persuaded the district to offer a full week of Jamie Oliver-inspired recipes in place of the regular lunch menu at Copper Hill School.” 1

The menu will include Beefy Nachos, Crusty Mac-n-Cheese, Sloppy Joe Sandwiches, Shepherd’s Pie, and Pizza. Are these foods health promoting? View the menu and Jamie’s recipes for yourself. Would you let your kids eat that stuff?

There are no nutritious dishes made with significant amounts of vegetables and beans. Amazing that Jamie Oliver has moved the nation to associate good nutrition with cancer-causing concoctions like Sloppy Joes and Mac-n-Cheese instead of true health-promoting, anti-cancer whole foods like vegetables, berries, seeds and fresh fruits. White flour, ground beef and cheese are not vegetables; and the message is still lacking in this “revolution” that without eating significant vegetables and beans we are going to have a nation of cancer-prone, heart-attack prone, overweight individuals.

Our students graduate from elementary and high schools, colleges, and even professional schools (such as medical schools) without ever learning the most critical information about how to protect one’s precious health.  Even highly educated individuals do not have a clear knowledge of the foods that prevent and protect against disease.  By attempting to improve the nation’s diet without incorporating these health-promoting foods, we are merely moving the chess pieces around aimlessly, and sadly the public does not become more educated about health, only more confused.

We need a real revolution, not a phony one that diverts attention away from the real problem. A revolution that places the power and the responsibility for health in hands of the individual, and gives them the power to live a disease-free life; free of toxic drugs, invasive surgical procedures, and futile and expensive medical care that is all hype but adds little to our quality or length of life.  

 

 

 

1.  frsd.net on behalf of L. Braun; June 3, 2010