Women taking Fosamax for several years may be prone to femur fractures

Bisphosphonates (Fosamax, Boniva, Actonel, Reclast), along with calcium and vitamin D supplementation, are a common conventional treatment for osteoporosis. These drugs are even used for prevention of osteoporosis in those with osteopenia.x-ray
Bone tissue continually goes through a cycle of formation of new bone and breakdown of old bone. Bisphosphonates increase bone mineral density in the short term by reducing bone breakdown, essentially reducing bone loss. However, it is not the same as building natural, healthy bone with exercise.  Exercise is essential, and, in particular, exercising the back and legs. Muscle strength is the most accurate way of predicting bone strength and of predicting risk of falls. Strengthening muscles has been shown to be the most effective way to strengthen bone and protect against osteoporosis-related fractures.1 Compared to exercise, medications are relatively ineffective and may cause harm.

Since bisphosphonates accumulate in bone tissue and suppress bone turnover, there has been a concern about the strength and integrity of the medically treated bone. Apparently, the use of bisphosphonates actually causes the bones to become brittle despite the increase seen in bone mineral density. 

Several studies have reported the occurrence of specific and rare types of femur fractures in individuals (mostly women) who had been taking bisphosphonates, specifically alendronate (Fosamax), for approximately 4-8 years.2,3,4,5,6,7,8,9Two additional and more recent studies  have drawn more attention to this potential hazard.10 Long term users of alendronate (Fosamax) – were found to be at significantly higher incidence of fractures.11 A frightening detail of these reports is that the fractures had occurred under minimal trauma – these fractures are not from falls. In fact, in most cases, these women were performing low-energy exercise, sometimes just walking down a flight of stairs.12,13

These medications have other serious side effects as well, such as atrial fibrillation a heart rhythm disturbance. Prevention of osteoporosis and bone fractures does not need to involve potentially dangerous drugs. 

Primary causes of hip fractures

  • Poor nutrition
  • Sedentary lifestyle
  • Muscle weakness
  • Side effects of prescription drugs
  • Declining vision
  • Cigarette smoking
  • Vitamin D deficiency

Exercise is a crucial component of my recommendations - most hip fractures result from falls. So, naturally, by increasing muscle strength and balance you can improve stability and prevent these falls.14 

My recommendations for osteoporosis protection: 

1.      Eat a high nutrient diet

2.      Take the right supplements.

3.      Do the right osteoporosis fighting exercises. Swimming and biking will not do it. The best bone building exercises designed to strengthen muscles and bone and to improve balance, reducing the risk of falls are demonstrated in my DVD  Osteoporosis Protection For Life

Osteoporosis Protection for Life                                

Dr. Fuhrman's Osteoporosis Protection For Life DVD is an educational and invigorating program for combating osteopenia and osteoporosis that offers a significant improvement over drug-treatment. In this video, Dr. Fuhrman offers advice regarding diet, supplements, and exercise, and demonstrates the best exercises to effectively build strength and bone mass.


1 Rubin C, Turner AS, Muller R, et al. Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, noninvasive mechanical intervention. J Bone Min Res 2002;17:349-357.

2 Cermak K, Shumelinsky F, Alexiou J, et al. Case Reports: Subtrochanteric Femoral Stress Fractures after Prolonged Alendronate Therapy. Clin Orthop Relat Res. 2009 Dec 18. [Epub ahead of print]

3 Capeci CM, Tejwani NC. Bilateral low-energy simultaneous or sequential femoral fractures in patients on long-term alendronate therapy. J Bone Joint Surg Am. 2009 Nov;91(11):2556-61.

4 Goddard MS, Reid KR, Johnston JC, Khanuja HS. Atraumatic bilateral femur fracture in long-term bisphosphonate use. Orthopedics. 2009 Aug;32(8). pii: orthosupersite.com/view.asp?rID=41933..

5 Ing-Lorenzini K, Desmeules J, Plachta O, et al. Low-energy femoral fractures associated with the long-term use of bisphosphonates: a case series from a Swiss university hospital. Drug Saf. 2009;32(9):775-85.

6 Lenart BA, Lorich DG, Lane JM. Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate. N Engl J Med. 2008 Mar 20;358(12):1304-6.

7 Sayed-Noor AS, Sjödén GO. Case reports: two femoral insufficiency fractures after long-term alendronate

therapy. Clin Orthop Relat Res. 2009 Jul;467(7):1921-6. Epub 2009 Feb 6.

8 Neviaser AS, Lane JM, Lenart BA, et al. Low-energy femoral shaft fractures associated with alendronate use. J Orthop Trauma. 2008 May-Jun;22(5):346-50.

9 Kwek EB, Goh SK, Koh JS, Png MA, Howe TS. An emerging pattern of subtrochanteric stress fractures: a long-term complication of alendronate therapy? Injury. 2008 Feb;39(2):224-31. Epub 2008 Jan 28.

10 LA Times: http://latimesblogs.latimes.com/booster_shots/2010/03/bisphosphonates-osteoporosis-medications.html


11 Somford MP, Draijer FW, Thomassen BJ, et al. Bilateral fractures of the femur diaphysis in a patient with rheumatoid arthritis on long-term treatment with alendronate: clues to the mechanism of increased bone fragility. J Bone Miner Res. 2009 Oct;24(10):1736-40.

12 Somford MP, Geurts GF, den Teuling JW, et al. Long-Term Alendronate Use Not without Consequences? Int J Rheumatol. 2009;2009:253432. Epub 2010 Jan 27.

13 ABC News: Fosamax: Is Long Term Use of Bone Strengthening Drug Linked to Fractures? http://abcnews.go.com/GMA/OnCall/fosamax-long-term-bone-strengthening-drug-linked-fractures/story?id=10045179

14 Ueki S, Kasai T, Takato J et al. Production of a fall prevention exercise program considering suggestions from community-dwelling elderly. Nippon Koshu Eisei Zasshi. 2006;53(2):112-121.


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Comments (4) Read through and enter the discussion with the form at the end
Beth - March 17, 2010 9:10 AM

It would be helpful if the exercises that are helpful would be described a bit, rather than being referred to purchase a DVD. For instance, it would be helpful to let my mother (who's been taking Fosamax for years) know the types of things she should be doing (rather than taking the drug, playing golf, and walking). Then, she might be interested in a DVD, which I imagine would give more explicit instruction and detail. Thank you.

Peter - March 20, 2010 7:12 PM

I agree with the other person leaving a comment. Do you want to know what to do: Buy my DVD. What a humanitarian.

robin - March 22, 2010 11:19 AM

I Also Agree! It would be much more helpful to say what exercises are beneficial and then you could offer the dvd to those who are interested as an option (not as the only option).

Anu Sastri - January 26, 2012 1:20 PM

I have Lupus for almost a year and I purchased Dr.Furhman

'Eat to Live" and "Fasting for Health" has helped me tremendously.

I also have Osteoporosis and take Fosamax. My budget is tight and would be greatful to know what kind of excercises are good so that i can stop my medicine.

Thank you very much!



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